Updated News

New York, NY, Tuesday, December 22, 2020 — The S-Network Healthcare Innovation Index^SM (TICKER: PHIX) added six constituents and dropped four constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, December 20, 2020, changing the number of index components to 30.

The additions to PHIX were: Novavax, Inc. (TICKER: NVAX US), Constellation Pharmaceuticals, Inc (TICKER: CNST US), Jazz Pharmaceuticals, plc (TICKER: JAZZ US), Exelixis, Inc. (TICKER: EXEL US), Arcutis, Inc. (TICKER: ARQT US), Alexion Pharmaceuticals, Inc. (TICKER: ALXN US).

The deletions from PHIX were: uniQure N.V. (TICKER: QURE US), Sage Therapeutics, Inc. (TICKER: SAGE US), Enanta Pharmaceuticals Inc (TICKER: ENTA US), Moderna Inc (TICKER: MRNA US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com).

The S-Network Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the S-Network Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the S-Network Healthcare Innovation Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Healthcare Innovation Index^SM:                    TICKER: PHIX

Index: S-Network Healthcare Innovation Total Return Index^SM:  TICKER: PHIXTR

New York, NY, Tuesday, December 22, 2020 — The S-Network Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) added 47 constituents and dropped nine constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, December 20, 2020, changing the number of index components to 145.

The additions to PBMA were: Adverum Biotechnologies Inc (TICKER: ADVM US), Allovir Inc (TICKER: ALVR US), Applied Molecular Transport Inc. (TICKER: AMTI US), Arcturus Therapeutics Holdings Inc (TICKER: ARCT US), argenx SE (TICKER: ARGX US), Atara Biotherapeutics Inc (TICKER: ATRA US), Athenex Inc (TICKER: ATNX US), Beam Therapeutics Inc (TICKER: BEAM US), BioXcel Therapeutics Inc (TICKER: BTAI US), BridgeBio Pharma Inc (TICKER: BBIO US), Calliditas Therapeutics AB (TICKER: CALT US), Corcept Therapeutics Inc (TICKER: CORT US), Cytokinetics Inc (TICKER: CYTK US), Dr.Reddy's Laboratories Ltd (TICKER: RDY US), Editas Medicine Inc (TICKER: EDIT US), Endo International PLC (TICKER: ENDP US), Forma Therapeutics Holdings Inc (TICKER: FMTX US), Galapagos NV (TICKER: GLPG US), Generation Bio Co (TICKER: GBIO US), I-Mab (TICKER: IMAB US), ImmunoGen Inc (TICKER: IMGN US), Inhibrx Inc (TICKER: INBX US), Inovio Pharmaceuticals Inc (TICKER: INO US), Intellia Therapeutics Inc (TICKER: NTLA US), Intra-Cellular Therapies Inc (TICKER: ITCI US), Iovance Biotherapeutics Inc (TICKER: IOVA US), Keros Therapeutics Inc (TICKER: KROS US), Kura Oncology Inc (TICKER: KURA US), Legend Biotech Corp (TICKER: LEGN US), MacroGenics Inc (TICKER: MGNX US), NantKwest Inc (TICKER: NK US), Novavax Inc (TICKER: NVAX US), Ocular Therapeutix Inc (TICKER: OCUL US), Precigen Inc (TICKER: PGEN US), Prestige Consumer Healthcare Inc (TICKER: PBH US), Regenxbio Inc (TICKER: RGNX US), Replimune Group Inc (TICKER: REPL US), Revolution Medicines Inc (TICKER: RVMD US), Rhythm Pharmaceuticals Inc (TICKER: RYTM US), Sangamo Therapeutics Inc (TICKER: SGMO US), Scholar Rock Holding Corp (TICKER: SRRK US), Seres Therapeutics Inc (TICKER: MCRB US), Travere Therapeutics Inc (TICKER: TVTX US), Turning Point Therapeutics Inc (TICKER: TPTX US), Vericel Corp (TICKER: VCEL US), Xencor Inc (TICKER: XNCR US), Zogenix Inc (TICKER: ZGNX US).

The deletions from PBMA were: Adaptimmune Therapeutics PLC (TICKER: ADAP US), Akebia Therapeutics Inc (TICKER: AKBA US), Arvinas Inc (TICKER: ARVN US), Enanta Pharmaceuticals Inc (TICKER: ENTA US), Gossamer Bio Inc (TICKER: GOSS US), Moderna Inc (TICKER: MRNA US), Odonate Therapeutics Inc (TICKER: ODT US), Orchard Therapeutics PLC (TICKER: ORTX US), Veracyte Inc (TICKER: VCYT US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com).

The S-Network Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PBMA consists of small-cap and mid-cap pharmaceutical and biotechnology stocks listed on US stock exchanges that have either year on year sales growth or one or more drugs in Phase II or Phase III US FDA clinical trials.

Detailed information on the S-Network Biopharma Merger & Acquisition Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Medical Breakthroughs Index^SM:                    TICKER: PBMA

Index: S-Network Medical Breakthroughs Total Return Index^SM: TICKER: PBMATR

New York, NY, Thursday, December 17, 2020 — The S-Network Medical Breakthroughs Index^SM (TICKER: PMBI) will add 42 constituents and drop 28 constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, December 20, 2020, changing the number of index components to 102.

The additions to PMBI are: IMMUNOVANT INC (TICKER: IMVT US), INSMED INC (TICKER: INSM US), LEGEND BIOTECH CORP-ADR (TICKER: LEGN US), AGIOS PHARMACEUTICALS INC (TICKER: AGIO US), BLUEBIRD BIO INC (TICKER: BLUE US), ALLOVIR INC (TICKER: ALVR US), SERES THERAPEUTICS INC (TICKER: MCRB US), XENCOR INC (TICKER: XNCR US), INOVIO PHARMACEUTICALS INC (TICKER: INO US), FORMA THERAPEUTICS HOLDINGS (TICKER: FMTX US), ARCUS BIOSCIENCES INC (TICKER: RCUS US), SANGAMO THERAPEUTICS INC (TICKER: SGMO US), REGENXBIO INC (TICKER: RGNX US), KINIKSA PHARMACEUTICALS-A (TICKER: KNSA US), CYTOKINETICS INC (TICKER: CYTK US), TRAVERE THERAPEUTICS INC (TICKER: TVTX US), CELLDEX THERAPEUTICS INC (TICKER: CLDX US), VAXART INC (TICKER: VXRT US), ESPERION THERAPEUTICS INC (TICKER: ESPR US), RADIUS HEALTH INC (TICKER: RDUS US), VANDA PHARMACEUTICALS INC (TICKER: VNDA US), MIRUM PHARMACEUTICALS INC (TICKER: MIRM US), ZIOPHARM ONCOLOGY INC (TICKER: ZIOP US), EAGLE PHARMACEUTICALS INC (TICKER: EGRX US), GERON CORP (TICKER: GERN US), 89BIO INC (TICKER: ETNB US), PROTHENA CORP PLC (TICKER: PRTA US), ALTIMMUNE INC (TICKER: ALT US), AC IMMUNE SA (TICKER: ACIU US), IMMUNIC INC (TICKER: IMUX US), SELECTA BIOSCIENCES INC (TICKER: SELB US), GAMIDA CELL LTD (TICKER: GMDA US), CYTOMX THERAPEUTICS INC (TICKER: CTMX US), VERASTEM INC (TICKER: VSTM US), KEZAR LIFE SCIENCES INC (TICKER: KZR US), KAMADA LTD (TICKER: KMDA US), ALDEYRA THERAPEUTICS INC (TICKER: ALDX US), PROTARA THERAPEUTIC INC (TICKER: TARA US), FORTRESS BIOTECH INC (TICKER: FBIO US), APTINYX INC (TICKER: APTX US), CHIMERIX INC (TICKER: CMRX US), NUCANA PLC-ADR (TICKER: NCNA US).

The deletions from PMBI are: XOMA CORP (TICKER: XOMA US), MEDICINOVA INC (TICKER: MNOV US), EIDOS THERAPEUTICS INC (TICKER: EIDX US), DECIPHERA PHARMACEUTICALS IN (TICKER: DCPH US), Y-MABS THERAPEUTICS INC (TICKER: YMAB US), KURA ONCOLOGY INC (TICKER: KURA US), HERON THERAPEUTICS INC (TICKER: HRTX US), EPIZYME INC (TICKER: EPZM US), KARYOPHARM THERAPEUTICS INC (TICKER: KPTI US), IMMUNOGEN INC (TICKER: IMGN US), RIGEL PHARMACEUTICALS INC (TICKER: RIGL US), KALVISTA PHARMACEUTICALS INC (TICKER: KALV US), MIRATI THERAPEUTICS INC (TICKER: MRTX US), ACCELERON PHARMA INC (TICKER: XLRN US), KODIAK SCIENCES INC (TICKER: KOD US), ARROWHEAD PHARMACEUTICALS IN (TICKER: ARWR US), BLUEPRINT MEDICINES CORP (TICKER: BPMC US), UNITED THERAPEUTICS CORP (TICKER: UTHR US), ALLAKOS INC (TICKER: ALLK US), INFLARX NV (TICKER: IFRX US), ARAVIVE INC (TICKER: ARAV US), Merus NV (TICKER: MRUS US), MeiraGTx Holdings PLC (TICKER: MGTX US), Oyster Point Pharma Inc (TICKER: OYST US), Arcturus Therapeutics Holdings Inc (TICKER: ARCT US), G1 Therapeutics Inc (TICKER: GTHX US), Ardelyx Inc (TICKER: ARDX US), PDL BioPharma Inc (TICKER: PDLI US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Medical Breakthroughs Index^SM (TICKER: PMBI) is designed to capture research and development opportunities in the biotechnology industry. PMBI consists of small-cap and mid-cap biotechnology stocks listed on US stock exchanges that have one or more drugs in either Phase II or Phase III US FDA clinical trials.

Detailed information on the S-Network Medical Breakthroughs Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Medical Breakthroughs Index^SM:                    TICKER: PMBI

Index: S-Network Medical Breakthroughs Total Return Index^SM: TICKER: PMBITR

New York, NY, Thursday, September 10, 2020 — The S-Network Healthcare Innovation Index^SM (TICKER: PHIX) will add five constituents and drop five constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, September 20, 2020, maintaining the number of index components at 30.

The additions to PHIX are: ACADIA Pharmaceuticals Inc (TICKER: TGTX US), Cortexyme Inc (TICKER: RVNC US), NGM Biopharmaceuticals Inc (TICKER: SAGE US), Coherus BioSciences Inc (TICKER: AUPH US), Viela Bio Inc (TICKER: MRNA US).

The deletions from PHIX are: United Therapeutics Corp (TICKER: QURE US), MyoKardia Inc (TICKER: RETA US), Eidos Therapeutics Inc (TICKER: AKCA US), Odonate Therapeutics Inc (TICKER: MESO US), Orchard Therapeutics PLC (TICKER: EPZM US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the S-Network Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the S-Network Healthcare Innovation Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Healthcare Innovation Index^SM:                    TICKER: PHIX

Index: S-Network Healthcare Innovation Total Return Index^SM:  TICKER: PHIXTR

New York, NY, Thursday, June 11, 2020 — The S-Network Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) will add 23 constituents and drop nine constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, June 21, 2020, changing the number of index components to 105.

The additions to PBMA are: MESOBLAST LIMITED (TICKER: MESO US), AKEBIA THERAPEUTICS (TICKER: AKBA US), SORRENTO THERAPEUTICS, INC. (TICKER: SRNE US), ADAPTIMMUNE THERAPEUTICS (TICKER: ADAP US), KINIKSA PHARMACEUTICALS (TICKER: KNSA US), ARCUS BIOSCIENCES (TICKER: RCUS US), CORTEXYME, INC. (TICKER: CRTX US), KRYSTAL BIOTECH (TICKER: KRYS US), SPRINGWORKS THERAPEUTICS (TICKER: SWTX US), ARCUTIS INC (TICKER: ARQT US), VIELA BIO (TICKER: VIE US), IMMUNOVANT INC (TICKER: IMVT US), ROCKET PHARMACEUTICALS, INC (TICKER: RCKT US), TG THERAPEUTICS INC (TICKER: TGTX US), BAUSCH HEALTH COMPANIES (TICKER: BHC US), AURINIA PHARMACEUTICALS (TICKER: AUPH US), REVANCE THERAPEUTICS (TICKER: RVNC US), MORPHOSYS AG (TICKER: MOR US), Perrigo Company Plc (TICKER: PRGO US), Zentalis Pharmaceuticals, Inc. (TICKER: ZNTL US), Twist Bioscience Corp. (TICKER: TWST US), Caredx Inc (TICKER: CDNA US), Translate Bio, Inc. (TICKER: TBIO US).

The deletions from PBMA are: CARA THERAPEUTICS (TICKER: CARA US), ATHENEX INC (TICKER: ATNX US), ENDO INTERNATIONAL PLC (TICKER: ENDP US), RADIUS HEALTH, INC. (TICKER: RDUS US), Elanco Animal Health, Inc. (TICKER: ELAN US), DENALI THERAPEUTICS INC (TICKER: DNLI US), Myriad Genetics Inc (TICKER: MYGN US), Wave Life Sciences Ltd (TICKER: WVE US), Crispr Therapeutics Ag (TICKER: CRSP US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PBMA consists of small-cap and mid-cap pharmaceutical and biotechnology stocks listed on US stock exchanges that have either year on year sales growth or one or more drugs in Phase II or Phase III US FDA clinical trials.

Detailed information on the S-Network Biopharma Merger & Acquisition Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Medical Breakthroughs Index^SM:                    TICKER: PBMA

Index: S-Network Medical Breakthroughs Total Return Index^SM: TICKER: PBMATR

New York, NY, Thursday, June 11, 2020 — The S-Network Healthcare Innovation Index^SM (TICKER: PHIX) will add 10 constituents and drop 10 constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, June 21, 2020, maintaining the number of index components at 30.

The additions to PHIX are: TG Therapeutics Inc (TICKER: TGTX US), Revance Therapeutics, Inc. (TICKER: RVNC US), Sage Therapeutics, Inc. (TICKER: SAGE US), Aurinia Pharmaceuticals Inc. (TICKER: AUPH US), Moderna, Inc (TICKER: MRNA US), uniQure N.V. (TICKER: QURE US), Reata Pharmaceuticals, Inc. (TICKER: RETA US), Akcea Therapeutics, Inc. (TICKER: AKCA US), Mesoblast Limited (TICKER: MESO US), Epizyme, Inc. (TICKER: EPZM US).

The deletions from PHIX are: Acadia Pharmaceuticals Inc. (TICKER: ACAD US), Exelixis, Inc. (TICKER: EXEL US), Opko Health, Inc. (TICKER: OPK US), Ngm Biopharmaceuticals, Inc. (TICKER: NGM US), Ascendis Pharma A/S (TICKER: ASND US), Immunomedics, Inc (TICKER: IMMU US), Chemocentryx, Inc. (TICKER: CCXI US), Radius Health Inc. (TICKER: RDUS US), Endo International Plc (TICKER: ENDP US), Athenex Inc (TICKER: ATNX US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the S-Network Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the S-Network Healthcare Innovation Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Healthcare Innovation Index^SM:                     TICKER: PHIX

Index: S-Network Healthcare Innovation Total Return Index^SM: TICKER: PHIXTR

New York, NY, Thursday, June 11, 2020 — The S-Network Medical Breakthroughs Index^SM (TICKER: PMBI) will add 30 constituents and drop nine constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, June 21, 2020, changing the number of index components to 90.

The additions to PMBI are: EMERGENT BIOSOLUTIONS INC (TICKER: EBS US), ANAPTYSBIO INC (TICKER: ANAB US), IVERIC BIO INC (TICKER: ISEE US), ARAVIVE INC (TICKER: ARAV US), MOLECULAR TEMPLATES INC (TICKER: MTEM US), ARDELYX INC (TICKER: ARDX US), ADAPTIMMUNE THERAPEUTICS-ADR (TICKER: ADAP US), KARYOPHARM THERAPEUTICS INC (TICKER: KPTI US), ADURO BIOTECH INC (TICKER: ADRO US), BLUEPRINT MEDICINES CORP (TICKER: BPMC US), INFLARX NV (TICKER: IFRX US), SYROS PHARMACEUTICALS INC (TICKER: SYRS US), ARCTURUS THERAPEUTICS HOLDIN (TICKER: ARCT US), SCHOLAR ROCK HOLDING CORP (TICKER: SRRK US), PROQR THERAPEUTICS NV (TICKER: PRQR US), KODIAK SCIENCES INC (TICKER: KOD US), AVROBIO INC (TICKER: AVRO US), Y-MABS THERAPEUTICS INC (TICKER: YMAB US), MAGENTA THERAPEUTICS INC (TICKER: MGTA US), VIR BIOTECHNOLOGY INC (TICKER: VIR US), BIOXCEL THERAPEUTICS INC (TICKER: BTAI US), ARCUTIS BIOTHERAPEUTICS INC (TICKER: ARQT US), VIELA BIO INC (TICKER: VIE US), CEL-SCI CORP (TICKER: CVM US), AURINIA PHARMACEUTICALS INC (TICKER: AUPH US), MEI PHARMA INC (TICKER: MEIP US), XENON PHARMACEUTICALS INC (TICKER: XENE US), HERON THERAPEUTICS INC (TICKER: HRTX US), ARROWHEAD PHARMACEUTICALS IN (TICKER: ARWR US), AFFIMED NV (TICKER: AFMD US).

The deletions from PMBI are: CYTOMX THERAPEUTICS INC (TICKER: CTMX US), UROGEN PHARMA LTD (TICKER: URGN US), ORCHARD THERAPEUTICS PLC (TICKER: ORTX US), MACROGENICS INC (TICKER: MGNX US), AGENUS INC (TICKER: AGEN US), IMMUNOMEDICS INC (TICKER: IMMU US), BLUEBIRD BIO INC (TICKER: BLUE US), GLYCOMIMETICS INC (TICKER: GLYC US), PORTOLA PHARMACEUTICALS INC (TICKER: PTLA US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Medical Breakthroughs Index^SM (TICKER: PMBI) is designed to capture research and development opportunities in the biotechnology industry. PMBI consists of small-cap and mid-cap biotechnology stocks listed on US stock exchanges that have one or more drugs in either Phase II or Phase III US FDA clinical trials.

Detailed information on the S-Network Medical Breakthroughs Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Medical Breakthroughs Index^SM:                    TICKER: PMBI

Index: S-Network Medical Breakthroughs Total Return Index^SM: TICKER: PMBITR

New York, NY, Thursday, March 12, 2020 — The S-Network Healthcare Innovation Index^SM (TICKER: PHIX) will add five constituents and drop five constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, March 22, 2020, maintaining the number of index components at 30.

The additions to PHIX are: Chemocentryx Inc (TICKER: CCXI US), Orchard Therapeutics Plc (TICKER: ORTX US), Heron Therapeutics Inc. (TICKER: HRTX US), Acadia Pharmaceuticals Inc (TICKER: ACAD US), Ascendis Pharma A/S Adr (TICKER: ASND US).

The deletions from PHIX are: DECIPHERA PHARMACEUTICALS IN (TICKER: DCPH US), Theravance Biopharma Inc (TICKER: TBPH US), Epizyme Inc. (TICKER: EPZM US), Acceleron Pharma Inc. (TICKER: XLRN US), Cara Therapeutics Inc (TICKER: CARA US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the S-Network Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the S-Network Healthcare Innovation Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Healthcare Innovation Index^SM:                     TICKER: PHIX

Index: S-Network Healthcare Innovation Total Return Index^SM: TICKER: PHIXTR

New York, NY, Friday, December 13, 2019 — The S-Network Medical Breakthroughs Index^SM (TICKER: PMBI) will add 22 constituents and drop 29 constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, December 22, 2019, changing the number of index components to 69.

The additions to PMBI are: BLUEBIRD BIO INC (TICKER: BLUE US), INTERCEPT PHARMACEUTICALS IN (TICKER: ICPT US), PORTOLA PHARMACEUTICALS INC (TICKER: PTLA US), IRONWOOD PHARMACEUTICALS INC (TICKER: IRWD US), KARUNA THERAPEUTICS INC (TICKER: KRTX US), ZYMEWORKS INC (TICKER: ZYME US), ALECTOR INC (TICKER: ALEC US), COHERUS BIOSCIENCES INC (TICKER: CHRS US), SPRINGWORKS THERAPEUTICS INC (TICKER: SWTX US), ROCKET PHARMACEUTICALS INC (TICKER: RCKT US), CORTEXYME INC (TICKER: CRTX US), AKERO THERAPEUTICS INC (TICKER: AKRO US), APREA THERAPEUTICS INC (TICKER: APRE US), FREQUENCY THERAPEUTICS INC (TICKER: FREQ US), REPLIMUNE GROUP INC (TICKER: REPL US), CATALYST PHARMACEUTICALS INC (TICKER: CPRX US), MERUS NV (TICKER: MRUS US), XBIOTECH INC (TICKER: XBIT US), OYSTER POINT PHARMA INC (TICKER: OYST US), CYTOMX THERAPEUTICS INC (TICKER: CTMX US), KALVISTA PHARMACEUTICALS INC (TICKER: KALV US), XOMA CORP (TICKER: XOMA US).

The deletions from PMBI are: Anika Therapeutics Inc (TICKER: ANIK US), ACADIA PHARMACEUTICALS INC (TICKER: ACAD US), HALOZYME THERAPEUTICS INC (TICKER: HALO US), EMERGENT BIOSOLUTIONS INC (TICKER: EBS US), AGIOS PHARMACEUTICALS INC (TICKER: AGIO US), Y-MABS THERAPEUTICS INC (TICKER: YMAB US), CARA THERAPEUTICS INC (TICKER: CARA US), RHYTHM PHARMACEUTICALS INC (TICKER: RYTM US), KINIKSA PHARMACEUTICALS-A (TICKER: KNSA US), AC IMMUNE SA (TICKER: ACIU US), MAGENTA THERAPEUTICS INC (TICKER: MGTA US), PROGENICS PHARMACEUTICALS (TICKER: PGNX US), PROQR THERAPEUTICS NV (TICKER: PRQR US), ANAPTYSBIO INC (TICKER: ANAB US), AMAG PHARMACEUTICALS INC (TICKER: AMAG US), XENON PHARMACEUTICALS INC (TICKER: XENE US), CORBUS PHARMACEUTICALS HOLDI (TICKER: CRBP US), MANNKIND CORP (TICKER: MNKD US), SCHOLAR ROCK HOLDING CORP (TICKER: SRRK US), MINERVA NEUROSCIENCES INC (TICKER: NERV US), ATHERSYS INC (TICKER: ATHX US), MARKER THERAPEUTICS INC (TICKER: MRKR US), ADURO BIOTECH INC (TICKER: ADRO US), PHASEBIO PHARMACEUTICALS INC (TICKER: PHAS US), ACORDA THERAPEUTICS INC (TICKER: ACOR US), SAVARA INC (TICKER: SVRA US), Achillion Pharmaceuticals Inc (TICKER: ACHN US), Arqule Inc (TICKER: ARQL US), Ra Pharmaceuticals (RARX US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Medical Breakthroughs Index^SM (TICKER: PMBI) is designed to capture research and development opportunities in the biotechnology industry. PMBI consists of small-cap and mid-cap biotechnology stocks listed on US stock exchanges that have one or more drugs in either Phase II or Phase III US FDA clinical trials.

Detailed information on the S-Network Medical Breakthroughs Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Medical Breakthroughs Index^SM:                    TICKER: PMBI

Index: S-Network Medical Breakthroughs Total Return Index^SM: TICKER: PMBITR

New York, NY, Wednesday, December 11, 2019 — The S-Network Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) will add 33 constituents and drop 11 constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, December 22, 2019, changing the number of index components to 113.

The additions to PBMA are: Radius Health, Inc. (TICKER: RDUS US), Kodiak Sciences Inc. (TICKER: KOD US), Ngm Biopharmaceuticals, Inc. (TICKER: NGM US), Karyopharm Therapeutics, Inc. (TICKER: KPTI US), Odonate Therapeutics, Inc. (TICKER: ODT US), Wave Life Sciences Ltd. (TICKER: WVE US), ArQule, Inc. (TICKER: ARQL US), Principia Biopharma Inc. (TICKER: PRNB US), Cara Therapeutics, Inc. (TICKER: CARA US), Alector  Inc (TICKER: ALEC US), Vir Biotechnology, Inc (TICKER: VIR US), Y-mAbs Therapeutics, Inc (TICKER: YMAB US), Axsome Therapeutics, Inc. (TICKER: AXSM US), Veracyte Inc (TICKER: VCYT US), Constellation Pharmaceuticals, Inc (TICKER: CNST US), Myovant Sciences Ltd. (TICKER: MYOV US), Dicerna Pharmaceuticals, Inc. (TICKER: DRNA US), DENALI THERAPEUTICS INC (TICKER: DNLI US), Zymeworks Inc. (TICKER: ZYME US), Chemocentryx, Inc. (TICKER: CCXI US), Karuna Therapeutics, Inc (TICKER: KRTX US), Myriad Genetics Inc (TICKER: MYGN US), Invitae Corp (TICKER: NVTA US), Ra Pharmaceuticals, Inc. (TICKER: RARX US), Deciphera Pharmaceuticals, LLC (TICKER: DCPH US), Natera  Inc. (TICKER: NTRA US), Arvinas, Inc. (TICKER: ARVN US), Spark Therapeutics, Inc. (TICKER: ONCE US), CRISPR Therapeutics AG (TICKER: CRSP US), BioNTech SE (TICKER: BNTX US), Catalent Inc (TICKER: CTLT US), Elanco Animal Health, Inc. (TICKER: ELAN US), Exact Sciences Corp (TICKER: EXAS US).

The deletions from PBMA are: AnaptysBio, Inc (TICKER: ANAB US), Atara Biotherapeutics, Inc. (TICKER: ATRA US), Aerie Pharmaceuticals, Inc (TICKER: AERI US), Editas Medicine, Inc (TICKER: EDIT US), Halozyme Therapeutics, Inc. (TICKER: HALO US), Vertex Pharmaceuticals Incorporated (TICKER: VRTX US), Grifols Sa (TICKER: GRFS US), Galapagos Nv (TICKER: GLPG US), China Biologic Products Holdings Inc (TICKER: CBPO US), Amarin Corp Plc Adr (TICKER: AMRN US), Morphosys Ag-Sponsored Adr (TICKER: MOR US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PBMA consists of small-cap and mid-cap pharmaceutical and biotechnology stocks listed on US stock exchanges that have either year on year sales growth or one or more drugs in Phase II or Phase III US FDA clinical trials.

Detailed information on the S-Network Biopharma Merger & Acquisition Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Medical Breakthroughs Index^SM:                    TICKER: PBMA

Index: S-Network Medical Breakthroughs Total Return Index^SM: TICKER: PBMATR

New York, NY, Wednesday, December 11, 2019 — The S-Network Healthcare Innovation Index^SM (TICKER: PHIX) will add 13 constituents and drop 13 constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, December 22, 2019, maintaining the number of index components at 30.

The additions to PHIX are: MYOVANT SCIENCES LTD (TICKER: MYOV US), MADRIGAL PHARMACEUTICALS INC (TICKER: MDGL US), NEKTAR THERAPEUTICS (TICKER: NKTR US), RADIUS HEALTH INC (TICKER: RDUS US), AXSOME THERAPEUTICS INC (TICKER: AXSM US), KARYOPHARM THERAPEUTICS INC (TICKER: KPTI US), ENDO INTERNATIONAL PLC (TICKER: ENDP US), CARA THERAPEUTICS INC (TICKER: CARA US), UNITED THERAPEUTICS CORP (TICKER: UTHR US), ODONATE THERAPEUTICS INC (TICKER: ODT US), SUPERNUS PHARMACEUTICALS INC (TICKER: SUPN US), NGM BIOPHARMACEUTICALS INC (TICKER: NGM US), DECIPHERA PHARMACEUTICALS IN (TICKER: DCPH US).

The deletions from PHIX are: ASCENDIS PHARMA A/S - ADR (TICKER: ASND US), PACIRA BIOSCIENCES INC (TICKER: PCRX US), MIRATI THERAPEUTICS INC (TICKER: MRTX US), ACADIA PHARMACEUTICALS INC (TICKER: ACAD US), HERON THERAPEUTICS INC (TICKER: HRTX US), PTC THERAPEUTICS INC (TICKER: PTCT US), EMERGENT BIOSOLUTIONS INC (TICKER: EBS US), UNIQURE NV (TICKER: QURE US), MEDICINES COMPANY (TICKER: MDCO US), TEVA PHARMACEUTICAL-SP ADR (TICKER: TEVA US), REATA PHARMACEUTICALS INC-A (TICKER: RETA US), ANAPTYSBIO INC (TICKER: ANAB US), Tricida, Inc. (TICKER: TCDA US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the S-Network Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the S-Network Healthcare Innovation Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Healthcare Innovation Index^SM:                     TICKER: PHIX

Index: S-Network Healthcare Innovation Total Return Index^SM: TICKER: PHIXTR

New York, NY, Thursday, September 12, 2019 — The S-Network Healthcare Innovation Index^SM (TICKER: PHIX) will add eight constituents and drop eight constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, September 22, 2019, maintaining the number of index components at 30.

The additions to PHIX are: Aimmune Therapeutics  Inc. (TICKER: AIMT US), Insmed Inc (TICKER: INSM US), Opko Health Inc (TICKER: OPK US), Ascendis Pharma A/S Adr (TICKER: ASND US), Exelixis Inc (TICKER: EXEL US), Ptc Therapeutics Inc (TICKER: PTCT US), Teva Pharmaceutical-Sp Adr (TICKER: TEVA US), Emergent Biosolutions Inc (TICKER: EBS US).

The deletions from PHIX are: Beigene Ltd-Adr (TICKER: BGNE US), Supernus Pharmaceuticals Inc (TICKER: SUPN US), Arena Pharmaceuticals Inc (TICKER: ARNA US), Fibrogen Inc (TICKER: FGEN US), Gossamer Bio Inc (TICKER: GOSS US), Madrigal Pharmaceuticals Inc (TICKER: MDGL US), Allakos, Inc. (TICKER: ALLK US), Atara Biotherapeutics Inc. (TICKER: ATRA US).

A complete list of constituents and weights will be posted on the S-Network Medical Indexes^SM website (snetmedicalindexes.com), as of the effective date.

The S-Network Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the S-Network Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the S-Network Healthcare Innovation Index^SM including constituent data, rules and price information is available at snetmedicalindexes.com. Data is also available through most vendors of financial data.

Index: S-Network Healthcare Innovation Index^SM: TICKER: PHIX

Index: S-Network Healthcare Innovation Total Return Index^SM: TICKER: PHIXTR

New York, NY, Wednesday, June 12, 2019 — The Poliwogg Healthcare Innovation Index^SM (TICKER: PHIX) will add 13 constituents and drop 13 constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, June 23, 2019, maintaining the number of index components at 30.

The additions to PHIX are: ACCELERON PHARMA (TICKER: XLRN US), ATHENEX, INC. (TICKER: ATNX US), BIOHAVEN PHARMACEUTICAL (TICKER: BHVN US), ENANTA PHARMACEUTICALS (TICKER: ENTA US), APELLIS PHARMACEUTICALS (TICKER: APLS US), EIDOS THERAPEUTICS, INC (TICKER: EIDX US), EPIZYME (TICKER: EPZM US), TRICIDA, INC (TICKER: TCDA US), GOSSAMER BIO INC. (TICKER: GOSS US), ALLAKOS INC (TICKER: ALLK US), ARENA PHARMACEUTICALS (TICKER: ARNA US), PACIRA PHARMACEUTICALS (TICKER: PCRX US), FIBROGEN, INC. (TICKER: FGEN US).

The deletions from PHIX are: NEUROCRINE BIOSCIENCES, INC. (TICKER: NBIX US), HORIZON THERAPEUTICS (TICKER: HZNP US), AGIOS PHARMACEUTICALS (TICKER: AGIO US), EMERGENT BIOSOLUTIONS (TICKER: EBS US), ARRAY BIOPHARMA, INC. (TICKER: ARRY US), SAGE THERAPEUTICS (TICKER: SAGE US), HUTCHISON CHINA MEDITECH LIMITED (TICKER: HCM US), JAZZ PHARMACEUTICALS, PLC (TICKER: JAZZ US), BLUEBIRD BIO (TICKER: BLUE US), AERIE PHARMACEUTICALS (TICKER: AERI US), Clovis Oncology Inc. (TICKER: CLVS US), Myovant Sciences Ltd (TICKER: MYOV US), RHYTHM PHARMACEUTICALS INC (TICKER: RYTM US).

A complete list of constituents and weights will be posted on the Poliwogg Medical Indexes^SM website (www.poliwoggindexes.com), as of the effective date.

The Poliwogg Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the Poliwogg Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the Poliwogg Healthcare Innovation Index^SM including constituent data, rules and price information is available at www.poliwoggindexes.com. Data is also available through most vendors of financial data.

Index: Poliwogg Healthcare Innovation Index^SM: TICKER: PHIX

Index: Poliwogg Healthcare Innovation Total Return Index^SM: TICKER: PHIXTR

New York, NY, Wednesday, June 12, 2019 — The Poliwogg Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) will add 16 constituents and drop 12 constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, June 23, 2019, changing the number of index components to 94.

The additions to PBMA are: Fate Therapeutics, Inc. (TICKER: FATE US), Epizyme, Inc. (TICKER: EPZM US), Moderna, Inc. (TICKER: MRNA US), Apellis Pharmaceuticals, Inc. (TICKER: APLS US), Coherus Biosciences, Inc. (TICKER: CHRS US), Athenex (TICKER: ATNX US), Eidos Therapeutics Inc (TICKER: EIDX US), Gossamer Bio Inc. (TICKER: GOSS US), Tilray Inc. (TICKER: TLRY US), Mylan, Inc. (TICKER: MYL US), Morphosys AG (TICKER: MOR US), Teva Pharmaceutical Industries Ltd (TICKER: TEVA US), Catalent Inc (TICKER: CTLT US), Phibro Animal Health Corporation A (TICKER: PAHC US), Opko Health Inc (TICKER: OPK US), Veracyte Inc (TICKER: VCYT US).

The deletions from PBMA are: DBV Technologies SA (TICKER: DBVT US), Intersect Ent, Inc. (TICKER: XENT US), Clovis Oncology Inc (TICKER: CLVS US), Regenxbio Inc. (TICKER: RGNX US), Rhythm Pharmaceuticals, Inc. (TICKER: RYTM US), G1 Therapeutics (TICKER: GTHX US), Spark Therapeutics, Inc. (TICKER: ONCE US), CRISPR Therapeutics AG (TICKER: CRSP US), Kiniksa Pharmaceuticals Ltd. (TICKER: KNSA US), Myovant Sciences Ltd. (TICKER: MYOV US), Biocryst Pharmaceuticals, Inc. (TICKER: BCRX US), Acorda Therapeutics, Inc (TICKER: ACOR US).

A complete list of constituents and weights will be posted on the Poliwogg Medical Indexes^SM website (www.poliwoggindexes.com), as of the effective date.

The Poliwogg Biopharma Merger & Acquisition Index^SM (TICKER: PBMA) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PBMA consists of small-cap and mid-cap pharmaceutical and biotechnology stocks listed on US stock exchanges that have either year on year sales growth or one or more drugs in Phase II or Phase III US FDA clinical trials.

Detailed information on the Poliwogg Biopharma Merger & Acquisition Index^SM including constituent data, rules and price information is available at www.poliwoggindexes.com. Data is also available through most vendors of financial data.

Index: Poliwogg Medical Breakthroughs Index^SM: TICKER: PBMA

Index: Poliwogg Medical Breakthroughs Total Return Index^SM: TICKER: PBMATR

New York, NY, Wednesday, June 12, 2019 — The Poliwogg Medical Breakthroughs Index^SM (TICKER: PMBI) will add 28 constituents and drop 20 constituents in its semi-annual reconstitution, effective 6:00 PM (ET) Sunday, June 23, 2019, changing the number of index components to 76.

The additions to PMBI are: DICERNA PHARMACEUTICALS INC (TICKER: DRNA US), CONSTELLATION PHARMACEUTICAL (TICKER: CNST US), ALKERMES PLC (TICKER: ALKS US), EPIZYME INC (TICKER: EPZM US), CRINETICS PHARMACEUTICALS IN (TICKER: CRNX US), RA PHARMACEUTICALS INC (TICKER: RARX US), PUMA BIOTECHNOLOGY INC (TICKER: PBYI US), PRINCIPIA BIOPHARMA INC (TICKER: PRNB US), ALLAKOS INC (TICKER: ALLK US), SCHOLAR ROCK HOLDING CORP (TICKER: SRRK US), ASSEMBLY BIOSCIENCES INC (TICKER: ASMB US), PROQR THERAPEUTICS NV (TICKER: PRQR US), AKCEA THERAPEUTICS INC (TICKER: AKCA US), MEIRAGTX HOLDINGS PLC (TICKER: MGTX US), ORCHARD THERAPEUTICS PLC (TICKER: ORTX US), Y-MABS THERAPEUTICS INC (TICKER: YMAB US), MAGENTA THERAPEUTICS INC (TICKER: MGTA US), EIDOS THERAPEUTICS INC (TICKER: EIDX US), GOSSAMER BIO INC (TICKER: GOSS US), ACADIA PHARMACEUTICALS INC (TICKER: ACAD US), ANIKA THERAPEUTICS INC (TICKER: ANIK US), AGENUS INC (TICKER: AGEN US), RIGEL PHARMACEUTICALS INC (TICKER: RIGL US), MARKER THERAPEUTICS INC (TICKER: MRKR US), MORPHOSYS AG ADR (TICKER: MOR US), PHASEBIO PHARMACEUTICALS INC (TICKER: PHAS US), DECIPHERA PHARMACEUTICALS IN (TICKER: DCPH US), MANNKIND CORP (TICKER: MNKD US).

The deletions from PMBI are: ADAMAS PHARMACEUTICALS INC (TICKER: ADMS US), NUCANA PLC-ADR (TICKER: NCNA US), ARBUTUS BIOPHARMA CORP (TICKER: ABUS US), AKEBIA THERAPEUTICS INC (TICKER: AKBA US), FLEXION THERAPEUTICS INC (TICKER: FLXN US), ASCENDIS PHARMA A/S - ADR (TICKER: ASND US), TOCAGEN INC (TICKER: TOCA US), CALITHERA BIOSCIENCES INC (TICKER: CALA US), ATARA BIOTHERAPEUTICS INC (TICKER: ATRA US), SYROS PHARMACEUTICALS INC (TICKER: SYRS US), CRISPR THERAPEUTICS AG (TICKER: CRSP US), SYNLOGIC INC (TICKER: SYBX US), ABEONA THERAPEUTICS INC (TICKER: ABEO US), INSMED INC (TICKER: INSM US), ARRAY BIOPHARMA INC (TICKER: ARRY US), CASI PHARMACEUTICALS INC (TICKER: CASI US), MEI PHARMA INC (TICKER: MEIP US), CATALYST PHARMACEUTICALS INC (TICKER: CPRX US), FIVE PRIME THERAPEUTICS INC (TICKER: FPRX US), GALAPAGOS NV-SPON ADR (TICKER: GLPG US).

A complete list of constituents and weights will be posted on the Poliwogg Medical Indexes^SM website (www.poliwoggindexes.com), as of the effective date.

The Poliwogg Medical Breakthroughs Index^SM (TICKER: PMBI) is designed to capture research and development opportunities in the biotechnology industry. PMBI consists of small-cap and mid-cap biotechnology stocks listed on US stock exchanges that have one or more drugs in either Phase II or Phase III US FDA clinical trials.

Detailed information on the Poliwogg Medical Breakthroughs Index^SM including constituent data, rules and price information is available at www.poliwoggindexes.com. Data is also available through most vendors of financial data.

Index: Poliwogg Medical Breakthroughs Index^SM: TICKER: PMBI

Index: Poliwogg Medical Breakthroughs Total Return Index^SM: TICKER: PMBITR

New York, NY, Friday, March 8, 2019 — The Poliwogg Healthcare Innovation Index^SM (TICKER: PHIX) will add 12 constituents and drop 10 constituents in its quarterly reconstitution, effective 6:00 PM (ET) Sunday, March 17, 2019, changing the number of index components to 30.

The additions to PHIX are: Madrigal Pharmaceuticals Inc (TICKER: MDGL US), Clovis Oncology Inc. (TICKER: CLVS US), Jazz Pharmaceuticals Plc (TICKER: JAZZ US), Emergent Biosolutions Inc (TICKER: EBS US), Neurocrine Biosciences Inc (TICKER: NBIX US), Heron Therapeutics Inc. (TICKER: HRTX US), Beigene Ltd-Adr (TICKER: BGNE US), Hutchison China Meditech-Adr (TICKER: HCM US), Atara Biotherapeutics Inc. (TICKER: ATRA US), Supernus Pharmaceuticals Inc (TICKER: SUPN US), Bluebird Bio Inc (TICKER: BLUE US), Horizon Pharma Plc (TICKER: HZNP US).

The deletions from PHIX are: Fibrogen Inc (TICKER: FGEN US), Alexion Pharmaceuticals Inc (TICKER: ALXN US), Acceleron Pharma Inc. (TICKER: XLRN US), Arena Pharmaceuticals Inc (TICKER: ARNA US), Alnylam Pharmaceuticals Inc (TICKER: ALNY US), Biohaven Pharmaceutical Holding Company Ltd. (TICKER: BHVN US), Pacira Pharmaceuticals Inc (TICKER: PCRX US), Alder Biopharmaceuticals Inc. (TICKER: ALDR US), Acorda Therapeutics (TICKER: ACOR US), Dbv Technologies Sa-Spon Adr (TICKER: DBVT US).

A complete list of constituents and weights will be posted on the Poliwogg Medical Indexes^SM website (www.poliwoggindexes.com), as of the effective date.

The Poliwogg Healthcare Innovation Index (TICKER: PHIX) is designed to capture merger and acquisition opportunities in the biotechnology and pharmaceutical industries. PHIX consists of companies included in the Poliwogg Biopharma Merger & Acquisition Index (PBMA) that pass additional screens.

Detailed information on the Poliwogg Healthcare Innovation Index^SM including constituent data, rules and price information is available at www.poliwoggindexes.com. Data is also available through most vendors of financial data.

Index: Poliwogg Healthcare Innovation Index^SM: TICKER: PHIX

Index: Poliwogg Healthcare Innovation Total Return Index^SM: TICKER: PHIXTR